advanced search

<< Back To Home

DETERMINANTS OF PER-COITAL-ACT HIV-1 INFECTIVITY AMONG AFRICAN HIV-1 SERODISCORDANT COUPLES

Thursday, 26th of January 2012

'Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision.'

Abstract below; full text available to JID subscribers

 J Infect Dis. 2012 Feb;205(3):358-365. Epub 2012 Jan 11. Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscordant Couples.

Hughes JP, Baeten JM, Lingappa JR, Magaret AS, Wald A, de Bruyn G, Kiarie J, Inambao M, Kilembe W, Farquhar C, Celum C; the Partners in Prevention HSV/HIV Transmission Study Team. SourceDepartment of Biostatistics.

Abstract (See the editorial commentary by Gray and Wawer on pages 351-2.) Background. Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1. Methods. We analyzed data from a prospective study of African HIV-1-serodiscordant couples. We assessed transmissions for linkage within the study partnership, based on HIV-1 sequencing. The primary exposure measure was the HIV-1-seropositive partners' reports of number of sex acts and condom use with their study partner. Results. Of 3297 couples experiencing 86 linked HIV-1 transmissions, the unadjusted per-act risks of unprotected male-to-female (MTF) and female-to-male (FTM) transmission were 0.0019 (95% confidence interval [CI], .0010-.0037) and 0.0010 (95% CI, .00060-.0017), respectively. After adjusting for plasma HIV-1 RNA of the HIV-1-infected partner and herpes simplex virus type 2 serostatus and age of the HIV-1-uninfected partner, we calculated the relative risk (RR) for MTF versus FTM transmission to be 1.03 (P = .93). Each log(10) increase in plasma HIV-1 RNA increased the per-act risk of transmission by 2.9-fold (95% CI, 2.2-3.8). Self-reported condom use reduced the per-act risk by 78% (RR = 0.22 [95% CI, .11-.42]).

Conclusions. Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision.

PMID:22241800[PubMed - as supplied by publisher] •
Supplemental ContentRelated citations Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. [N Engl J Med. 2010] Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N, Mujugira A, Baeten JM, Mullins JI, Hughes JP, et al. N Engl J Med. 2010 Feb 4; 362(5):427-39. Epub 2010 Jan 20.Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons. [BMC Res Notes. 2011] Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected Persons. Mujugira A, Magaret AS, Baeten JM, Celum C, Lingappa J. BMC Res Notes. 2011 Mar 15; 4:64. Epub 2011 Mar 15.National Institute of Mental Health Multisite Eban HIV/STD Prevention Intervention for African American HIV Serodiscordant Couples: a cluster randomized trial. [Arch Intern Med. 2010] National Institute of Mental Health Multisite Eban HIV/STD Prevention Intervention for African American HIV Serodiscordant Couples: a cluster randomized trial. El-Bassel N, Jemmott JB, Landis JR, Pequegnat W, Wingood GM, Wyatt GE, Bellamy SL, NIMH Multisite HIV/STD Prevention Trial for African American Couples Group. Arch Intern Med. 2010 Sep 27; 170(17):1594-601. Epub 2010 Jul 12.Review Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. [Cochrane Database Syst Rev. 2008] Review Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Johnson WD, Diaz RM, Flanders WD, Goodman M, Hill AN, Holtgrave D, Malow R, McClellan WM. Cochrane Database Syst Rev. 2008 Jul 16; (3):CD001230. Epub 2008 Jul 16.Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. [Cochrane Database Syst Rev. 2011] Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. Anglemyer A, Rutherford GW, Baggaley RC, Egger M, Siegfried N. Cochrane Database Syst Rev. 2011 Aug 10; (8):CD009153. Epub 2011 Aug 10.See reviews... See all... Recent activity Clear Turn Off Turn On Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscord... Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscordant Couples. J Infect Dis. 2012 Feb;205(3):358-365. Epub 2012 Jan 11.PubMedinambao (18) PubMedYour browsing activity is empty. Activity recording is turned off. Turn recording back on See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI DirectoryGetting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Resources Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation Popular PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure Featured GenBank Reference Sequences Map Viewer Genome Projects Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI Information About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA PreferencesTurn off •