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Summary Points
Full text is at http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000398
Vaccines for malaria eradication need to have an impact on transmission rather than focusing on mortality and morbidity reduction alone
Vaccines that interrupt malaria transmission (VIMT) may target many stages of the parasite’s life cycle, not just the sexual and mosquito stages as in classical blocking vaccines and multiple plasmodium species, in particular Plasmodium vivax
Novel vaccine delivery approaches and adjuvants need to be developed
Other priority areas for research and development include the development of tools to measure transmission rates and the development of robust assays of functional immune responses in individuals, which could inform vaccine development
A better understanding of the dynamics between the multiplication of parasites, gametocytogenesis, and malaria transmission rates in populations is also needed