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CSU 134/2011: A RESEARCH AGENDA FOR MALARIA ERADICATION: VACCINES

Saturday, 16th of April 2011 Print

Summary Points

Full text is at http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000398

Vaccines for malaria eradication need to have an impact on transmission rather than focusing on mortality and morbidity reduction alone

Vaccines that interrupt malaria transmission (VIMT) may target many stages of the parasite’s life cycle, not just the sexual and mosquito stages as in classical blocking vaccines and multiple plasmodium species, in particular Plasmodium vivax

Novel vaccine delivery approaches and adjuvants need to be developed

Other priority areas for research and development include the development of tools to measure transmission rates and the development of robust assays of functional immune responses in individuals, which could inform vaccine development

A better understanding of the dynamics between the multiplication of parasites, gametocytogenesis, and malaria transmission rates in populations is also needed

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